Anabolic steroids, bodybuilding discussion forums. - SteroidologyAnabolic androgenic steroids effects on the immune system: Central European journal of biology, 4 1 Access the Journal's homepage. Androgenic anabolic somatropin tabletten kaufen AAS are can anabolic steroids weaken immune system derivatives of the male hormone testosterone. While several adverse effects of AAS abuse have been described, their effect on the immune system has not been clearly elucidated.
Does Gear lower your immune system? | liveriga.info
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Circlejerk-ish or off-topic posts may be removed. To avoid a flood of basic questions, new readers cannot create new topics. After 90 days of participation comments in the community, you will be automatically approved to create new topics. So yesterday one of the top stories on Reddit was: The general discussion in the top comments was that chronic inflammatory, autoimmune diseases such as psoriasis, Chron's, rheumatoid arthritis, Sjogren's syndrome etc.
This is the generally accepted conclusion as dictated by current research. I thought to myself that since this is the case, we should hear anecdotal reports of AAS users being alleviated of symptoms associated with some of those autoimmune diseases during AAS cycles due to the immunosuppressive effects of AAS.
After a few google searches, sure enough I found some:. In order to follow sub-rules, I am not posting links to forums laden with ads, but you can google the following if interested: But then I got confused as hell while chasing the rabbit hole, when I came across this study: I found other studies supporting the same thing: In this abstract , the researchers note that "literature generally indicates that supraphysiologic doses of AAS with an intact steroid nucleus are immunosuppressive, that is they reduce immune cell number and function.
While those with alterations to the steroid nucleus are immunostimulatory as they induce the proliferation of T cells and other immune cells. Specifically, several common AAS have been shown to adversely influence lymphocyte differentiation and proliferation, antibody production, Natural Killer Cytotoxic activity and the production of certain cytokines, thereby altering the immune reaction.
Another study, Anabolic steroid effects on immune function: The chemistry of it all is a bit over my head, but what I am gathering is that if a modification, for a reason unknown to me, is made to the "steroid nucleus", or the gonane , the steroid has more immunostimulatory properties versus if left unaltered, immunosuppressive.
If someone smarter than me can make sense of this, please let me know if this sounds right. I don't want to be spreading misinformation. Also, what counts as a modification? Do the modifications in red in this image count? If so, why is nandrolone seem to be an immunostimulant, but with no modifications made to the gonane?
I get that being immunosuppressive versus immunostimulant may not be as black and white as just having and altered gonane or not. It makes sence given the seemingly countless mechanisms in which steroids act on an organism, that it could be a combination of things. Similarly, I understand that "immune system" is a hugely broad term, and that AAS can affect one or more components of that system. I just wanted to see if others could provide insight. Additionally, what have your experiences been with autoimmune disorders and AAS?
Additional and helpful reading for those interested: Since I got back on AAS 6 months ago, I haven't had a single injury, sniffle, cough or anything reminiscent of sickness. I was thinking this the other day. My ulcerative colitis and psoriasis both get helped a lot by gear. I run tren and low test year round. Nandrolone and test also gave similar results. What kinda dose of tren does one run year round?
Ive heard of people cruising for long periods on super low tren and test but havent discussed too many first hand experiences. Whats your blood work look like? I had to take a year off from lifting due to injuries so my tren was typically around mg a week and test mg.
My bloodwork is fine, i wasn't even polycythemic during this time. Damn thats not even as low of a dose as I was thinking. Thanks for the response. Kind of interesting to see your blood work was all in line. Im pretty sure I could hold a pretty insane look all year around if I added mg of tren to my HRT test dose.
Makes me want to try it and see if I can keep my kidneys healthy. Did you ever have night sweats or insomnia with tren on any dose? I have at 75mg per day, so I am wondering if a slightly lower dose would solve that problem. If I could keep my bloods good and actually sleep I looked pretty good cruising on that until i couldn't workout anymore and had to come off all gear, even my hrt, for 9 weeks.
I sweat more than the average joe, but i always have, and insomnia and shit like that doesnt happen to me unless i massively increase the dose and i only got it my first tren blast. Im on mg ed and hunger, sweating, and brutal pumps are the only sides i have. Just curious, how old are you? Tale hcg or just chill w small nuts? Mid 20s, i run tren year round for my cruise at a low dose.
It helps with my medical ailments more than test ever did so even if i weren't into lifting I would take it. No hcg, don't want kids yet anyways. I have secondary hypogonadism so I essentially do an advanced form of hrt. The second effect occurs later and is observed only with certain analogues after 10 days of treatment. This could result from the negative feedback suppression by the analogs of the natural immuno-inhibitor, testosterone. This effect was seen only with analogues in which the steroid nucleus was altered so that the com- pound cannot be converted to testosterone our treatment Groups 3, 4, and 5.
In this situation in intact non-castrate animals, a net immuno- stimulation was seen which was abolished by the addition of physiological amounts of testos- terone. In castrated animals, the modulation of testosterone secretion being abolished, the second stimulatory effect is no longer present. Only the early direct immuno-suppressive effect is observed The other important point was that all of them were suppressive in the first few days, but later became stimulatory.
So to answer your question, basically anything that differs from testosterone is stimulatory in the end because natural testosterone is shut down. When most steroids were developed, it was most important that they build muscle, and their binding to cells in the immune system was probably not studied well.
So, they likely don't exert the same effect on the immune system like testosterone does. A quick google also shows test is related to a weakened immune system. Interesting, so you're saying that analogues not related to test will still obviously shut you down, but in the absence of test, known to cause immunosupression, the immune system can improve and appear to be stimulated. I have alopecia small bald patch near my forehead that developed in May. I've been on TRT for around 4 weeks now and I'm noticing a ton of new growth in that spot and I hope to have it filled in a few more weeks.
I still have no idea why the alopecia happened in the first place. In addition to trt, are you taking anything to control conversion to DHT? Yes, Nizoral shampoo but I don't know if it's effective.
The first hairs in my bald spot popped out around 48 hours from my first shot and I had already been using the shampoo for 2 weeks with no results. I had alopecia several years ago. All the hair grew back after a few months - there was no rhyme or reason to it. I'm not a doctor or anything, but I can tell you that since I've hopped on test, some deca my allergies have gotten MUCH better. I also seem to be getting sick less, and if I do get the sniffles, I get better sooner.
Not to mention any small cuts heal a helluva lot faster than before. A small cut used to take up to a week to heal, now it's history in 2 days. Was going through some old posts and found this.